Artifact Key

The  is a new item in Risk of Rain 2. It is randomly dropped by enemies in Bulwark's Ambry during an Artifact challenge. They are used to interact with the to damage it, which is otherwise completely impervious to normal damage. When used, every item in the stack is consumed.

The Artifact Key's drop chance is not affected by  or.

It is one of the three items that the artifact of command doesn't work for.