Health

The health gauge of Risk of Rain 2 is displayed in the bottom-left corner of the screen on the HUD. Taking damage reduces your health. Lost health regenerates over time.

Health Regeneration
All survivors and some Monsters regenerate health passively. The amount per second is determined by the character's base Health Regeneration, character level, and certain items such as Cautious Slug, Rejuvenation Rack, and Titanic Knurl.

Proc effects
Lost health can also be replenished through proc effects such as Leeching Seed and Harvester's Scythe, active items such as Foreign Fruit, and healing drones. The max health gain from Infusion also heals for 1 point, and counts as healing in game terms, preventing you from completing the Naturopath achievement. Incoming healing is modified by items like Rejuvenation Rack and Corpsebloom.

1-Shot Protection
A player cannot lose more than 90% of their maximum health in one hit from an enemy attack. Shields are considered part of your maximum health for this calculation.

Death
When a survivor's health reaches zero, he dies. If all survivors in the group are dead, the run ends. A statistics screen appears. Dio's Best Friend causes you to return to life once upon death with full health.