Artifact Key

The  is a boss item in Risk of Rain 2. It is randomly dropped by enemies in Bulwark's Ambry during an Artifact Trial. They are used to interact with and damage the, which is otherwise completely impervious to normal damage. When used, all Artifact Keys in the player's inventory, as well as those still on the field, are consumed, preventing the player from stockpiling them.

The Artifact Key's drop chance is not affected by the or, and it will drop even if the  is not enabled.

It is one of few items that the has no effect on. Though a Yellow Command Essence will drop, it cannot be transformed into any item except the Artifact Key.